Click here to Order
Click here to download a Biometic Products brochure
The composition of our Bioglass is 45S5 and is currently available in two forms:
– Granules
– Powder (50µm diameter)
Custom formulations are also available upon request.
(All Bioglass is research grade only – not for human clinical use)
Costs (USD, Incl GST (tax))
| Quantity | 50g | 100g |
|---|---|---|
| Granules | 265.00 | 400.00 |
| Powder(50µm diameter) | 330.00 | 510.00 |
– Gamma sterilisation incurs 10% surcharge
– Does not include shipping costs
Contextual Information
Bioglass (a particular form of bioactive glass) is an established bioactive-bioabsorbable material that remains at the forefront of tissue engineering developments, orthopaedic and dentistry fillers, and cosmetics. It is one of the few biomaterials that readily facilitates both soft and hard tissue attachment. The bioactive hydrated silica layer that forms on surface supports cell-matrix adhesion and facilitates tissue ingrowth and conduction. Bioglass may also be used to induce radioopacity as a tag, coating or filler for gels, polymers and polymer textiles.
Bioglass contains less than 60 mol% SiO2, high Na2O and CaO contents, high CaO/P2O5 ratio which makes Bioglass highly reactive to aqueous medium and bioactive.
Five inorganic reaction stages occur at the bioglass surface when a bioglass is immersed in a physiological environment. These are:
- Ion exchange in which modifier cations (mostly Na+) in the glass exchange with hydronium ions in the external solution.
- Hydrolysis in which Si-O-Si bridges are broken, forming Si-OH silanol groups, and the glass network is disrupted.
- Condensation of silanols in which the disrupted glass network changes its morphology to form a gel-like surface layer, depleted in sodium and calcium ions
- Precipitation in which an amorphous calcium phosphate layer is deposited on the gel
- Mineralization in which the calcium phosphate layer gradually transforms into crystalline hydroxyapatite, that mimics the mineral phase naturally contained with vertebrate bones.
Using DNA microarrays, researchers have identified entire classes of genes that are regulated by the dissolution products of bioglass. Early microarray studies on bioglass demonstrated that genes associated with osteoblast growth and differentiation, maintenance of extracellular matrix, and promotion of cell-cell and cell-matrix adhesion were up-regulated by conditioned cell culture media containing the dissolution products of bioglass.
